PCa Commentary # 146: Radium-223 (Xofigo); A Radioisotope Treatment for Prostate Cancer Metastatic to Bone. The radiobiology of Radium-223 suggests greater effectiveness when used early in metastatic castration-resistant prostate cancer (mCRPC).

by Dr. Ed Weber | Oct 7, 2020 | PCa Commentary

In 2013 Radium-223 was FDA approved for treatment of prostate cancer patients with bone metastases on the basis of a large randomized trial, ASYMPCA, comparing the radioisotope to a placebo. In 708 heavily pretreated men, the overall median survival was extended by...

PCa Commentary # 145: PSA, PSA Dynamics, and Advances in Imaging: PSA and the PSADT (PSA doubling time) Guide the Management of Prostate Cancer.

by Dr. Ed Weber | Oct 7, 2020 | PCa Commentary

Following radical prostatectomy [and radiation therapy] for organ confined disease, approximately one-third of men will develop a biochemical relapse with a detectable PSA level.”  Quoted from “PSA Doubling Time and Absolute PSA Predict Metastases-free Survival in Men...

PCa Commentary #144: THE CHECKPOINT INHIBITORS – In Search of a Role in the Treatment of Prostate Cancer: The Current Status.

by Dr. Ed Weber | Sep 1, 2020 | PCa Commentary

PCa Commentary #143: ANTI-PSMA 177-LUTETIUM RADIOLIGAND THERAPY: An Update on Outcomes; the Vision Trial; and Future Directions

by Dr. Ed Weber | Feb 26, 2020 | PCa Commentary

Three new modalities for treatment of advanced prostate cancer are in development that will significantly impact management and extend overall survival:  immunotherapy with checkpoint blockade;  poly ADP-ribosepolymerase (PARP) inhibitors; and  anti-PSMA radioligand...

PCa Commentary #142 ANTI TUMOR IMMUNE RESPONSE POTENTIATED by RADIOTHERAPY: A concept arising from pre clinical studies now is clinically supported by the results of the ORIOLE trial.

by Dr. Ed Weber | Feb 4, 2020 | PCa Commentary

The ORIOLE TRIAL, “Primary Outcomes of a Phase II Randomized Trial of Observation Versus Stereotactic Ablative Radiotherapy for Oligometastatic Prostate Cancer,” Phillips et al., Int. J. Radiation Oncology Biology Physics, November 1, 2019 The study had two...