Prostate Cancer Gleason Score

Interpreting the Prostate Cancer Biopsy

What is a Prostate Cancer Gleason Score? A biopsy may be recommended after abnormal results from the standard screen tests, a Digital Rectal Exam combined with a PSA Test. The biopsy is normally performed using transrectal ultrasound guidance. The ultrasound will allow the physician to take distributed samples from the prostate. Usually twelve separate samples are taken. A pathologist will then examine the tissue samples under a microscope to determine whether or not the prostate contains cancerous tissue.

What is a Prostate Cancer Gleason Score? A biopsy may be recommended after abnormal results from the standard screen tests, a Digital Rectal Exam combined with a PSA Test. The biopsy is normally performed using transrectal ultrasound guidance. The ultrasound will allow the physician to take distributed samples from the prostate. Usually twelve separate samples are taken. A pathologist will then examine the tissue samples under a microscope to determine whether or not the prostate contains cancerous tissue.

When cancer is discovered, it is classified by a Prostate Cancer Gleason Score. A Prostate Cancer Gleason Score or Grade helps to determine how aggressively the prostate cancer is likely to behave. The score will help classify the cancer by grading how quickly it it is likely to grow. The score also is a an indicator in how likely it is to spread outside of the prostate gland.

  • The Prostate Cancer Gleason Score score ranges from 2 to 10.
  • To determine the Gleason score, the pathologist uses a microscope to look at the patterns of cells in the prostate tissue.
  • The most common cell pattern is given a grade of 1 (most like normal cells) to 5 (most abnormal).
  • If there is a second most common cell pattern, the pathologist gives it a grade of 1 to 5.
  • The pathologist adds the two most common grades together to make the Gleason score. If only one pattern is seen, the pathologist counts it twice, e.g. 5 + 5 = 10.
  • A high Gleason score (such as 10) means a high-grade prostate tumor.
  • High-grade tumors are more likely than low-grade tumors to grow quickly and spread.
Prostate Cancer Gleason Score

How Does the Pathologist Grade the Prostate Cancer Gleason Score?

Gleason Score 1

The cancerous tissue looks very much like normal prostate cells.

Gleason Score 2-4

Some cells do look like normal prostate cells, other cells do not. Patterns of cells in these grades vary.

Gleason Score 5

The cells appear abnormal and do not look like normal prostate cells. Abnormal cells appear to be scattered haphazardly throughout the prostate.

 NOTE: The pathologist adds the two most common grades together to make the final Gleason score.

Advice for Men Diagnosed with Prostate Cancer

Edward Weber, M.D. offers advice For Patients of Prostate Cancer. It is important to be informed, but you do not need to do this alone. That is what the specialists are there for. This is the time for deliberation, since once treated you cannot reverse the course. Watch this video to learn more.

  UNDERSTAND PROSTATE CANCER.

Prostate Cancer

What is Prostate Cancer?

What is Prostate Cancer, the Symptoms, Risk Factors? What does the Prostate do, where is it located?

Prostate Cancer Tests and Diagnostics

Diagnosed with Prostate Cancer?

What tests confirm the presence of prostate cancer? Learn how doctors diagnose prostate cancer.

Prostate Cancer Treatments

Treating Prostate Cancer.

Patients have options when it comes to the prostate cancer treatments. Learn about your options.

Explore Common Prostate Cancer Terms

To Learn More, Click on Any of the Terms Below

Prostate Cancer Treatment Options

Which TREATMENTS are most likely to leave patients PROSTATE CANCER FREE?  Testing PSA  levels in thousands of patients for years following treatment, identifies which are most effective.  See which course of therapy worked best for patients with low to high risk cancer.   Get your copy of the study to discuss with your family and Doctor.

Get The Study

Help other men make better treatment decisions.

A $25 donation today helps us continue the groundbreaking working of the Prostate Cancer Treatment Study Group.